Fungal genomics (San-Diego; London, 2007). - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаFungal genomics / ed. by J.C.Dunlap. - San-Diego; London: Academic Press, 2007. - xiii, 302 p., [4] p. of plates : ill. (some col.), map. - (Advances in genetics; vol.57). - Incl. bibl. ref. - Ind.: p.285-302. - ISBN-10 0-12-017657-2; ISBN-13 978-0-12-017657-1
 

Оглавление / Contents
 
   Contributors ................................................ ix
   Preface ................................................... xiii

1  Genetics of Morphogenesis and Pathogenic Development of
   Ustilago maydis .............................................. 1
   Steven J. Klosterman, Michael H. Perlin, Maria
   Garcia-Pedrajas, Sarah F. Covert, and Scott E. Gold
   I    Introduction ............................................ 3
   II   Mating .................................................. 4
   III  Dimorphism ............................................. 12
   IV   Cell Cycle and Cytoskeletal Regulation ................. 17
   V    Pathogenesis ........................................... 21
   VI   Genome-Wide Approaches for the Study of U. maydis ...... 27
   VII  The Plant Side of the Disease Equation ................. 36
   VIII Conclusion ............................................. 38
   References .................................................. 38

2  Enabling a Community to Dissect an Organism: Overview of
   the Neurospora Functional Genomics Project .................. 49
   Jay C. Dunlap, Katherine A. Borkovich, Matthew R. Henn,
   Gloria E. Turner, Matthew S. Sachs, N. Louise Glass,
   Kevin McCluskey, Michael Plamann, James E. Galagan,
   Bruce W. Birren, Richard L. Weiss, Jeffrey P. Townsend,
   Jennifer J. Loros, Mary Anne Nelson, Randy Lambreghts,
   Hildur V. Colot, Gyungsoon Park, Patrick Collopy, Carol
   Ringelberg, Christopher Crew, Liubov Litvinkova, Dave
   DeCaprio, Heather M. Hood, Susan Curilla, Mi Shi, Matthew
   Crawford, Michael Koerhsen, Phil Montgomery, Lisa Larson,
   Matthew Pearson, Takao Kasuga, Chaoguang Tian, Meray
   Bafturkmen, Lorena Altamirano, and Junhuan Xu
   I    Introduction ........................................... 51
   II   Project 1: Systematic Gene Knockouts ................... 56
   III  Project 2: Genome Informatics and Functional
        Annotation Studies ..................................... 71
   IV   Project 3: Profiling Transcription in Neurospora ....... 78
   V    Project 4: cDNA Libraries and the Generation of a
        High-Density SNP Map ................................... 85
   VI   Conclusions ............................................ 93
   References .................................................. 93

3  Genomics of the Plant Pathogenic Oomycete Phytophthora:
   Insights into Biology and Evolution ......................... 97
   Howard S. Judelson
   I    Introduction ........................................... 98
   II   Advances in Structural Genomics ....................... 100
   III  Organization of Phytophthora Genomes .................. 104
   IV   Other Genetic Elements ................................ 114
   V    Tools for Functional Genomics ......................... 115
   VI   Selected Areas of Phytophthora Research ............... 118
   VII  Conclusions and Prospects ............................. 131
   References ................................................. 132

4  Sex and Virulence of Human Pathogenic Fungi ................ 143
   Kirsten Nielsen and Joseph Heitman
   I    The Predominant Human Pathogenic Fungi ................ 144
   II   Sex in Fungal Pathogens: Cost Versus Benefit .......... 146
   III  Mating-Type Loci Are the Sex-Determining Regions in
        Fungi ................................................. 148
   IV   Sex in Cryptococcus ................................... 149
   V    The Unusual Cryptococcus Mating-Type Locus ............ 153
   VI   Genome Sequencing Identified Mating-Type Locus
        in the "Asexual" C. albicans and Led to the
        Discovery of Mating ................................... 153
   VII  Mating-Type Locus in A. fumigatus ..................... 157
   VIII Mating-Type Loci in Other Human Pathogenic Fungi ...... 157
   IX   Population Genetic Studies in "Asexual" Fungi Reveal
        Evidence of Sex ....................................... 159
   X    The Role of Sex in Pathogenesis ....................... 162
   XI   Concluding Remarks .................................... 165
   References ................................................. 166

5  From Genes to Genomes: A New Paradigm for Studying Fungal
   Pathogenesis in Magnaporthe oryzae ......................... 175
   Jin-Rong Xu, Xinhua Zhao, and Ralph A. Dean
   I    Introduction .......................................... 176
   II   Attachment and Appressorium Morphogenesis ............. 177
   III  Mechanisms of Penetration ............................. 187
   IV   Invasive Growth and Host-Pathogen Interactions ........ 190
   V    Genes and Genome Features ............................. 195
   VI   Functional Genomics ................................... 204
   VII  Concluding Remarks .................................... 208
   References ................................................. 209

6  Genetic and Genomic Dissection of the Cochliobolus
   heterostrophus Tox1 Locus Controlling Biosynthesis of
   the Polyketide Virulence Factor T-toxin .................... 219
   B. Gillian Turgeon and Scott E. Baker
   I    Introduction .......................................... 220
   II   Tools for Genetic Analysis ............................ 228
   III  C. heterostrophus and SCLB ............................ 233
   IV   The Genetics of T-Toxin Production .................... 235
   V    Genomic Analysis of the Tox1 Locus .................... 242
   VI   The PM-Toxin Gene Cluster ............................. 247
   VII  Are Additional Tox Loci Involved in T-Toxin
        Production? ........................................... 249
   VIII Model for Biosynthesis of T-Toxin ..................... 250
   IX   The Evolution of Polyketide-Mediated Fungal
        Specificity for T-Cytoplasm Corn ...................... 252
   X    Conclusions ........................................... 254
   References ................................................. 255

7  Fungal Genomics: A Tool to Explore Central Metabolism of
   Aspergillus fumigatus and Its Role in Virulence ............ 263
   Taylor Schoberle and Gregory S. May
   I    Introduction .......................................... 264
   II   Nutritional Auxotrophy and Fungal Genetics ............ 265
   III  Regulation of Amino Acid Biosynthesis ................. 268
   IV   Regulation of Ambient pH Response ..................... 272
   V    Regulation of Nitrogen Response Pathways .............. 275
   VI   Regulation of Carbon Response Pathways ................ 277
   VII  Concluding Remarks .................................... 281
   References ................................................. 281

   Index ...................................................... 285


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