Preface ..................................................... XV
List of Contributors ...................................... XVII
1 Basic Electromagnetic Theory of SERS ......................... 1
Pablo G. Etchegoin and Eric C. Le Ru
1.1 Introduction 1
1.2 Plasmon Resonances and Field Enhancements ............... 2
1.3 Field Enhancement Distribution and Localization ........ 20
1.4 Electromagnetic Model for the SERS and Fluorescence
Enhancement Factors .................................... 23
1.5 The Magnitude of the SERS Enhancement Factor in
Typical Cases .......................................... 32
1.6 Conclusions ............................................ 33
References .................................................. 34
2 Nanoparticle SERS Substrates ................................ 39
Yuling Wang and Erkang Wang
2.1 Introduction ........................................... 39
2.2 Preparation and Stability of Metal Nanoparticle
Colloidal SERS Substrates .............................. 40
2.3 Characterization of Nanoparticle-Based SERS
Substrates ............................................. 57
2.4 Nanoparticles on the Unfunctionalized Solid Surface
as SERS Substrates ..................................... 58
2.5 Conclusion and Outlook ................................. 60
References ............................................. 60
3 Quantitative SERS Methods ................................... 71
Steven E.J. Bell and Alan Stewart
3.1 Introduction ........................................... 71
3.2 SERS Media ............................................. 71
3.3 Stability and Shelf Life ............................... 73
3.4 Reproducibility and Internal Standards ................. 74
3.5 Selectivity ............................................ 78
3.6 Conclusion ............................................. 82
References .................................................. 83
4 Single-Molecule- and Trace Detection by SERS ................ 87
Nicholas P.W. Pieczonka, Golam Moula, Adam R. Skarbek,
and Ricardo F. Aroca
4.1 Introduction ........................................... 87
4.2 Experiments and Results ................................ 90
4.3 Conclusions ............................................ 99
References .................................................. 99
5 Detection of Persistent Organic Pollutants by Using SERS
Sensors Based on Organically Functionalized Ag
Nanoparticles .............................................. 103
Luca Guerrini, Patricio Leyton, Marcelo Campos-Vallette,
Conception Domingo, José V. Garcia-Ramos, and Santiago
Sanchez-Cortes
5.1 Introduction .......................................... 103
5.2 Inclusion Hosts ....................................... 106
5.3 Contact Hosts ......................................... 115
5.4 Occlusion Hosts ....................................... 120
5.5 Conclusions ........................................... 122
Acknowledgements ........................................... 124
References ................................................. 124
6 SERS and Pharmaceuticals ................................... 129
Simona Cintă Pînzaru and Ioana E. Pavel
6.1 Introduction .......................................... 129
6.2 SERS of Antipyretics and Analgesics ................... 130
6.3 SERS of Antimalarials ................................. 139
6.4 SERS of Anticarcinogenics and Antimutagenics .......... 142
6.5 Concluding Remarks .................................... 152
References ................................................. 152
7 SERS and Separation Science ................................ 155
Alison J. Hobro and Bemhard Lendl
7.1 Introduction .......................................... 155
7.2 SERS and Capillary Electrophoresis (CE) ............... 157
7.3 SERS and Liquid Chromatography (LC) ................... 161
7.4 SERS and Gas Chromatography (GC) ...................... 164
7.5 SERS and Thin Layer Chromatography (TLC) .............. 165
7.6 Other Separation Methods .............................. 166
7.7 Conclusions ........................................... 169
References ................................................. 169
8 SERS and Microfluidics ..................................... 173
Thomas Henkel, Anne März, and Jürgen Popp
8.1 Introduction .......................................... 173
8.2 Lab-on-a-chip Technology .............................. 174
8.3 Microfluidic Platforms and Application for SERS ....... 176
8.4 Summary ............................................... 187
References ................................................. 188
9 Electrochemical SERS and its Application in Analytical,
Biophysical and Life Science ............................... 191
Bin Ren, Yan Cui, De-Yin Wu, and Zhong-Qun Tian
9.1 Electrochemical Surface-Enhanced Raman Spectroscopy ... 191
9.2 Features of Electrochemical Surface-Enhanced Raman
Spectroscopy .......................................... 192
9.3 Experimental Techniques of EC-SERS .................... 197
9.4 Applications of EC-SERS ............................... 204
9.5 Perspectives .......................................... 213
References ................................................. 217
10 Electron Transfer of Proteins at Membrane Models ........... 219
Peter Hildebrandt, Jiu-Ju Feng, Anja Kranich, Khoa H. Ly,
Diego F. Martín, Marcelo Martí, Daniel H. Murgida,
Damián A. Paggi, Nattawadee Wisitruangsakul, Murat Sezer,
Inez M. Weidinger, and Ingo Zebger
10.1 Introduction .......................................... 219
10.2 Model Membranes and Membrane Models ................... 221
10.3 Methods for Probing Electron Transfer Processes of
Cytochrome с at Coated Electrodes ..................... 225
10.4 The Unusual Distance Dependence of the Interfacial
Electron Transfer Process ............................. 228
10.5 Electron Transfer and Protein Orientational
Dynamics .............................................. 231
10.6 Electric Field Effects on the Electron Transfer
Dynamics .............................................. 232
10.7 Electron Transfer and Protein Structural Changes ...... 234
10.8 Overall Description of the Mechanism and Dynamics
of the Interfacial Processes .......................... 235
10.9 Interfacial Electric Fields and the Biological
Functions of Cytochrome с ............................. 237
References ................................................. 239
11 Quantitative DNA Analysis Using Surface-Enhanced
Resonance Raman Scattering ................................. 241
Ross Stevenson, Karen Faulds, and Duncan Graham
11.1 Introduction .......................................... 241
11.2 SERRS Surfaces ........................................ 242
11.3 Raman Reporters ....................................... 245
11.4 SERRS DNA Probes ...................................... 248
11.5 Sensitivity ........................................... 252
11.6 Multiplexing .......................................... 253
11.7 Assays ................................................ 256
11.8 Conclusion ............................................ 259
References ................................................. 259
12 SERS Microscopy: Nanoparticle Probes and Biomedical
Applications ............................................... 263
Sebastian Schlücker
12.1 Introduction .......................................... 263
12.2 SERS Nanoparticle Probes .............................. 264
12.3 Biomedical Applications of SERS Microscopy ............ 272
12.4 Summary and Outlook ................................... 279
Acknowledgement ............................................ 280
References ................................................. 281
13 1-P and 2-P Excited SERS as Intracellular Probe ............ 285
Janina Kneipp
13.1 From Tags to Probes: Challenges in Intracellular
Probing ............................................... 285
13.2 Probing of Intracellular Parameters ................... 292
13.3 Surface-Enhanced Hyper Raman Scattering and Its
Potential in Studies of Cells ......................... 297
Acknowledgements ........................................... 301
References ................................................. 301
14 Surface-and Tip-Enhanced CARS ............................. 305
Taro Ichimura and Satoshi Kawata
14.1 Introduction ......................................... 305
14.2 CARS : Coherent Anti-Stokes Raman Scattering ......... 305
14.3 Local Enhancement of CARS by Metallic
Nanostructures ....................................... 307
14.4 Surface-Enhanced CARS ................................ 309
Index ...................................................... 323
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