Drug-DNA interaction protocols (New York, 2010). - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаDrug-DNA interaction protocols / ed. by K.R.Fox. - 2nd ed. - New York: Humana Press, 2010. - xi, 318 p.: ill. - (Springer protocols. Methods in molecular biology; 613). - Incl. bibl. ref. - Ind.: p.315-318. - ISSN 1064-3745; ISBN 978-1-60327-417-3
 

Оглавление / Contents
 
Preface ......................................................... v
Contributors ................................................... ix

1  Quantitative Analysis of Small Molecule-Nucleic Acid
   Interactions with a Biosensor Surface and Surface Plasmon
   Resonance Detection .......................................... 1
   Yang Liu and W. David Wilson
2  Thermal Melting Studies of Ligand DNA Interactions .......... 25
   Aurore Guédin, Laurent Lacroix, and Jean-Louis Mergny
3  Circular and Linear Dichroism of Drug-DNA Systems ........... 37
   Alison Rodger
4  Drug Binding to DNA-RNA Hybrid Structures ................... 55
   Richard T. Wheelhouse and Jonathan B. Chaires
5  Quantification of Binding Data Using Capillary
   Electrophoresis ............................................. 71
   Pitsumbirhan Araya, Graham G. Skellern, and Roger D. Waigh
6  Determination of Equilibrium Association Constants of
   Ligand-DNA Complexes by Electrospray Mass Spectrometry ...... 89
   Valérie Gabelica
7  Detection of Adriamycin-DNA Adducts by Accelerator Mass
   Spectrometry ............................................... 103
   Kate Coldwell, Suzanne M. Cutts, Ted J. Ognibene, Paul
   T. Henderson, and Don R. Phillips
8  Molecular Modelling Methods to Quantitate Drug-DNA 
   Interactions ............................................... 119
   Hao Wang and Charles A. Laughton
9  Application of Anomalous Diffraction Methods to the Study
   of DNA and DNA-Complexes ................................... 133
   Derrick Watkins, Tinoush Moulaei, Seiji Komeda, and 
   Loren Dean Williams
10 DNase I Footprinting ...................................... 153
   Antonia S. Cardew and Keith R. Fox
11 Methods to Characterize the Effect of DNA-Modifying
   Compounds on Nucleosomal DNA ............................... 173
   Vidya Subramanian, Robert M. Williams, Dale L. Boger,
   and Karolin Luger
12 REPSA: Combinatorial Approach for Identifying Preferred
   Drug-DNA Binding Sequences  ................................ 193
   Michael W. Van Dyke
13 In vitro Transcription Assay for Resolution of Drug-DNA
   Interactions at Defined DNA Sequences ...................... 207
   Benny J. Evison, Don R. Phillips, and Suzanne M. Cutts
14 In vitro Footprinting of Promoter Regions Within 
   Supercoiled Plasmid DNA .................................... 223
   Daekyu Sun
15 Topoisomerase I-Mediated DNA Relaxation as a Tool to 
   Study Intercalation of Small Molecules into Supercoiled
   DNA ........................................................ 235
   Paul Peixoto, Christian Bailly, and Marie-Hélène David-
   Cordonnier
16 A High-Throughput Assay for DNA Topoisomerases and Other
   Enzymes, Based on DNA Triplex Formation .................... 257
   Matthew R. Burrell, Nicolas P. Burton, and Anthony 
   Maxwell
17 Measurement of DNA Interstrand Crosslinking in Individual
   Cells Using the Single Cell Gel Electrophoresis (Comet)
   Assay ...................................................... 267
   Victoria J. Spanswick, Janet M. Hartley, and John 
   A. Hartley
18 Measurement of DNA Interstrand Crosslinking in Naked DNA
   Using Gel-Based Methods  ................................... 283
   Konstantinos Kiakos, Janet M. Hartley, and John 
   A. Hartley
19 An Evaluation Cascade for G-Quadruplex Telomere Targeting
   Agents in Human Cancer Cells ............................... 303
   Mekala Gunaratnam and Stephen Neidle

Index  ........................................................ 315


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