Historical Perspective .......................................... v
Contributors ................................................... ix
Chapter 1 Evolving Concepts of Atherothrombosis
Valentin Fuster, MD, PhD and Roberto Corti, MD .................. 1
Chapter 2 Cerebrovascular Diseases: Pathophysiology and
Management
Debabrata Mukherjee, MD and Jay S. Yadav, MD ................... 29
Chapter 3 Aortic Arch Vulnerable Plaques: Update
Pierre Amarenco, MD and Ariel Cohen, MD, PhD ................... 57
Chapter 4 The Vulnerable Atherosclerotic Plaque in
Peripheral Vascular Disease
Michael L. Marin, MD, Larry H. Hollier, MD,
Valentin Fuster, MD, PhD, and Jeffrey Goldman, MD .............. 85
Panel Discussion I. Overview of Pathology: Clinical
Correlations of Atherosclerosis ............................... 101
Chapter 5 Thermography: A Novel Approach for Identification
of Plaques at Risk of Rupture and/or Thrombosis
Mohammad Madjid, MD, Morteza Naghavi, MD,
James T. Willerson, MD, and Ward Casscells, MD ................ 107
Chapter 6 Intravascular Ultrasound and Plaque
Vulnerability: Evidence of a Systemic Disease
Process
Paul Schoenhagen, MD and Steven E. Nissen,
MD, FACC ...................................................... 129
Chapter 7 Intracoronary Angioscopy to Detect Vulnerable
Plaques: A Technique Whose Time Has Come?
Sergio Waxman, MD ............................................. 143
Chapter 8 Electron Beam Computed Tomography in Assessing
the Vulnerable Atherosclerotic Plaque
Robert A. O'Rourke, MD ........................................ 151
Chapter 9 Multirow-Detector Helical Computed Tomography
Christoph R. Becker, MD, Uwe J. Schoepf, MD, and
Maximilian F. Reiser, MD ...................................... 167
Panel Discussion IIA. Overview of Imaging: Coronary
Atherosclerosis ............................................... 175
Chapter 10 Imaging of the High-Risk Plaque Using Magnetic
Resonance Imaging
Zahi A. Fayad, PhD and Valentin Fuster, MD, PhD ............... 181
Chapter 11 Cardiovascular Imaging with Optical Coherence
Tomography
Mark E. Brezinski, MD, PhD and James Fujimoto,
PhD ........................................................... 201
Panel Discussion IIB. Overview of Imaging: Atherosclerotic
Regions and Imaging Modalities ................................ 219
Chapter 12 Plaque Instability and Remodeling: Mechanisms and
Possible Misconceptions
Trine-Line Korsholm, MS, Gerard Pasterkamp, MD,
PhD, MSc, and Erling Falk, MD, PhD ............................ 225
Chapter 13 Structural and Cellular Components of the
Vulnerable Plaque: Extracellular Matrix
Renu Virmani, MD, Frank D. Kolodgie, PhD, Allen
P. Burke, MD, Andrew Farb, MD, and Thomas N.
Wight, PhD .................................................... 241
Chapter 14 Structural and Cellular Components of the
Vulnerable Plaque: Inflammatory Cells
Allard C. van der Wal, MD, PhD, Mischa A.
Houtkamp, MSc, Onno J. de Boer, PhD, and Anton
E. Becker, MD, PhD ............................................ 251
Panel Discussion III. Structural and Cellular Components of
the Vulnerable Atherosclerotic Plaque ......................... 269
Chapter 15 Stress and Strain: Biomechanical Guides for
Imaging Plaque Stability
Hayden Huang, DSc and Richard T. Lee, MD ...................... 277
Chapter 16 Endothelium, Flow, and Atherothrombosis
Roberto Corti, MD, Lina Badimon, PhD, Valentin
Fuster, MD, PhD, and Juan Jose Badimon, PhD ................... 287
Chapter 17 Activities that Trigger Plaque Disruption
Jagmeet P. Singh, MD, DM, PhD, James Januzzi,
MD, and James E. Muller, MD ................................... 307
Panel Discussion IV. Mechanical Forces in Plaque Disruption ... 327
Chapter 18 Matrix Metalloproteinases and Their Inhibitors
Uwe Schönbeck, PhD and Peter Libby, MD ........................ 335
Chapter 19 Calcium Deposition in Vulnerable Atherosclerotic
Plaques: Pathophysiologic Mechanisms and
Potential Implications in the Acute Coronary
Syndromes
Pedro R. Moreno, MD ........................................... 347
Panel Discussion V. Regulation of Functional Components
of the Vulnerable Plaque ...................................... 365
Index ......................................................... 371
|
