Preface ......................................................... v
Contributors ................................................... xi
Section I Reactive Oxygen and Nitrogen Species ................. 1
1 In Vivo Imaging of Free Radicals and Oxygen .................. 3
Deepti S. Vikram, Brian K. Rivera, and Periannan Kuppusamy
2 In Vivo Measurement of Tissue Oxygen Using Electron
Paramagnetic Resonance Spectroscopy with Oxygen-Sensitive
Paramagnetic Particle, Lithium Phthalocyanine ............... 29
F. Hyodo, S. Matsumoto, E. Hyodo, A. Matsumoto,
K. Matsumoto, and M.C. Krishna
3 Measurement of Plasma Nitrite by Chemiluminescence .......... 41
Enika Nagababu and Joseph M. Rifkind
4 Determination of Glutathione, Mitochondrial Transmembrane
Potential, and Cytotoxicity in H9c2 Cardiomyoblasts
Exposed to Reactive Oxygen and Nitrogen Species ............. 51
K. Sathishkumar, Xueli Gao, Achuthan C. Raghavamenon,
Subramanyam N. Murthy, Philip J. Kadowitz, and Rao M. Uppu
Section II Natural and Synthetic Antioxidants .................. 63
5 Phenolic Acids and Flavonoids: Occurrence and Analytical
Methods ..................................................... 65
Constantine D. Stalikas
6 Design, Synthesis, and Action of Antiatherogenic
Antioxidants ................................................ 91
Osamu Cynshi, Kunio Tamura, and Etsuo Niki
7 Preparation of Drug-Loaded Polymeric Nanoparticles and
Evaluation of the Antioxidant Activity Against Lipid
Peroxidation ............................................... 109
Adriana R. Pohlmann, Scheila Rezende Schaffazick, Tânia
B. Creczynski-Pasa, and Silvia S. Guterres
8 Nanoparticle and Iron Chelators as a Potential Novel
Alzheimer Therapy .......................................... 123
Gang Liu, Ping Men, George Perry, and Mark A. Smith
9 Synthesis and Characterization of Polymer Nanocarriers
for the Targeted Delivery of Therapeutic Enzymes ........... 145
Eric Simone, Thomas Dziubla, Vladimir Shuvaev, and
Vladimir R. Muzykantov
10 Assessment of Antioxidant Activity of Eugenol In Vitro
and In Vivo ................................................ 165
Enika Nagababu, Joseph M. Rifkind, Sesikeran Boindala,
and Lakshmaiah Nakka
Section III Cellular Oxidative Stress ......................... 181
11 The Generation of Stable Oxidative Stress-Resistant Phenotypes
in Chinese Hamster Fibroblasts Chronically Exposed to Hydrogen
Peroxide or Hyperoxia ...................................... 183
Douglas R. Spitz and Shannon J. Sullivan
12 A Simple Method for Effective and Safe Removal of
Membrane Cholesterol from Lipid Rafts in Vascular
Endothelial Cells: Implications in Oxidant-Mediated Lipid
Signaling .................................................. 201
Michelle A. Kline, E.S. O'Connor Butler, Adam Hinzey,
Sean Sliman, Sainath R. Kotha, Clay B. Marsh, Rao
M. Uppu, and Narasimham L. Parinandi
13 Superoxide Dismutase - A Target for Gene Therapeutic
Approach to Reduce Oxidative Stress in Erectile
Dysfunction ................................................ 213
W. Deng, T.J. Bivalacqua, H.C. Champion, W.J. Hellstrom,
Subramanyam N. Murthy, and Philip J. Kadowitz
14 Assessing the Reductive Capacity of Cells by Measuring
the Recycling of Ascorbic and Lipoic Acids ................. 229
James M. May
15 Biomarkers of Oxidative Stress: Methods and Measures of
Oxidative DNA Damage (COMET Assay) and Telomere
Shortening ................................................. 245
Muthuswamy Balasubramanyam, Antonysunil Adaikalakoteswari,
Zaheer Sameermahmood, and Viswanathan Mohan
16 Simultaneous Analysis of Expression of Multiple Redox-
Sensitive and Apoptotic Genes in Hypothalamic Neurons
Exposed to Cholesterol Secoaldehyde ........................ 263
K. Sathishkumar, Achuthan C. Raghavamenon, Karunakaran
Ganeshkumar, Rameshwari Telaprolu, Narasimham L.
Parinandi, and Rao M. Uppu
17 Redox Homeostasis and Cellular Stress Response in Aging
and Neurodegeneration ...................................... 285
Vittorio Calabrese, Carolin Cornelius, Cesare Mancuso,
Riccardo Lentile, A.M. Giuffrida Stella, and D. Allan
Butterfield
18 Gene Therapy Techniques for the Delivery of Endothelial
Nitric Oxide Synthase to the Lung for Pulmonary
Hypertension ............................................... 309
W. Deng, T.J. Bivalacqua, H.C. Champion, W.J. Hellstrom,
Subramanyam N. Murthy, and Philip J. Kadowitz
Section IV DNA Oxidation, Oxidative Lipidomics, and
Biomarkers .................................................... 323
19 A General Method for Quantifying Sequence Effects on
Nucleobase Oxidation in DNA ................................ 325
Yelena Margolin and Peter C. Dedon
20 Analysis of Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
by Liquid Chromatography-Tandem Mass Spectrometry .......... 341
Mark D. Evans, Rajinder Singh, Vilas Mistry, Peter
B. Farmer, and Marcus S. Cooke
21 Oxidative Lipidomics of Apoptosis: Quantitative
Assessment of Phospholipid Hydroperoxides in Cells and
Tissues .................................................... 353
Vladimir A. Tyurin, Yulia Y. Tyurina, Vladimir B. Ritov,
Andriy Lysytsya, Andrew A. Amoscato, Patrick M. Kochanek,
Ronald Hamilton, Steven T. DeKosky, Joel S. Greenberger,
Hillya Bayir, and Valerian E. Kagan
22 Simultaneous Analysis of Multiple Lipid Oxidation
Products In Vivo by Liquid Chromatographic-Mass
Spectrometry (LC-MS) ....................................... 375
Huiyong Yin, Todd Davis, and Ned A. Porter
23 Lipoxygenase-Catalyzed Phospholipid Peroxidation:
Preparation, Purification, and Characterization of
Phosphatidylinositol Peroxides ............................. 387
E. Susan O'Connor Butler, Jessica N. Mazerik, Jason
P. Crujf, Shariq I. Sherwani, Barbara K. Weis, Clay
B. Marsh, Achuthan C. Raghavamenon, Rao M. Uppu, Harald
H.O. Schmid, and Narasimham L. Parinandi
24 Oxidized Low-Density Lipoprotein ........................... 403
Sampath Parthasarathy, Achuthan Raghavamenon, Mahdi Omar
Garelnabi, and Nalini Santanam
25 Detection and Localization of Markers of Oxidative Stress
by In Situ Methods: Application in the Study of Alzheimer
Disease .................................................... 419
Paula I. Moreira, Lawrence M. Sayre, Xiongwei Zhu,
Akihiko Nunomura, Mark A. Smith, and George Perry
26 Enzyme Immunoassay of Isoprostanes ......................... 435
Denis M. Callewaert and Charles Sloan
27 Application of Membrane Extraction with Sorbent Interface
for Breath Analysis ........................................ 451
Victor Ma, Heather Lord, Melissa Morley, and Janusz
Pawliszyn
Subject Index ................................................. 469
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