Photosensitive molecules for controlling biological function / ed. by J.J.Chambers, R.H.Kramer. - New York: Humana Press, 2011. - xiv, 297 p.: ill. - (Neuromethods; 55) (Springer protocols). - Incl. bibl. ref. - Ind.: p.287-297. - ISBN 978-1-61779-030-0; ISSN 0893-2236  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

Preface to the Series ........................................... v Preface ....................................................... vii Contributors ................................................. xiii Part I Photoreactive Small Molecules for Affecting Biological Function 1 Introduction to Part I: Caged Neurotransmitters .............. 3 James J. Chambers and Richard H. Kramer 2 Targeting and Excitation of Photoactivatable Molecules: Design Considerations for Neurophysiology Experiments ........ 7 Eugene F. Civillico, J. Peter Rickgauer, and Samuel S.-H. Wang 3 Are Caged Compounds Still Useful? ........................... 39 Graham C.R. Ellis-Davies 4 Chromophores for the Delivery of Bioactive Molecules with Two-Photon Excitation .................................. 57 Timothy M. Dore and Hunter C. Wilson Part II Imparting Light Sensitivity on Cells Using Photosensitive Proteins 5 Introduction to Part II: Natural Photosensitive Proteins .... 95 James J. Chambers and Richard H. Kramer 6 Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons ............................................ 99 Brian Y. Chow, Xue Han, Jacob G. Bernstein, Patrick E. Monahan, and Edward S. Boyden 7 Vertebrate and Invertebrate Rhodopsins: Light Control of G-Protein Signaling ....................... 133 Davina V. Gutierrez, Eugene Oh, and Stefan Herlitze 8 Restoring Visual Function After Photoreceptor Degeneration: Ectopic Expression of Photosensitive Proteins in Retinal Neurons .................................................... 147 Bin Lin and Richard H. Masland Part III Molecular Photoswitch Conjugates to Remotely Affect Activity 9 Introduction to Part III: Small Molecule Photoswitches ..... 167 James J. Chambers and Richard H. Kramer 10 Photoswitch Design ......................................... 171 Andrew A. Bebarry and G. Andrew Woolley 11 Photoswitchable Voltage-Gated Ion Channels ................. 185 Doris L. Fortin and Richard H. Kramer 12 Optical Manipulation of Protein Activity and Protein Interactions Using Caged Proteins and Optical Switch Protein Conjugates ......................................... 213 Yilling Yan and Gerard Marriott 13 Structure-Based Design of Light-Controlled Proteins ........ 233 Harald Janovjak and Ehud T. Isacoff 14 Photoswitchable Ligand-Gated Ion Channels .................. 267 Pau Gorostiza and Ehud Y. Isacoff Index ......................................................... 287