Foreword ...................................................... vii
Janko Nikolich-Žugich
Preface ........................................................ ix
INTRODUCTION
The Emergence of Geroscience as an Interdisciplinary Approach
to the Enhancement of Health Span and Life Span ................. 1
Felipe Sierra
PART I: BASIC MECHANISMS OF BIOLOGICAL AGING
The Role of the Microenvironmental Niche in Declining
Stem-Cell Functions Associated with Biological Aging ........... 15
Nathan A. DeCarolis, Elizabeth D. Kirby, Tony Wyss-Coray, and
Theo D. Palmer
Biochemical Genetic Pathways that Modulate Aging in Multiple
Species ........................................................ 25
Alessandro Bitto, Adrienne M. Wang, Christopher F. Bennett,
and Matt Kaeberlein
DNA Damage, DNA Repair, Aging, and Neurodegeneration ........... 51
Scott Maynard, Evandro Fei Fang, Morten Scheibye-Knudsen,
Deborah L. Croteau, and Wilhelm A. Bohr
How Research on Human Progeroid and Antigeroid Syndromes Can
Contribute to the Longevity Dividend Initiative ................ 69
Fuki M. Hisama, Junko Oshima, and George M. Martin
Dissecting the Mechanisms Underlying Successful Human Health
Span and Life Span ............................................. 93
Sofiya Milman and Mr Barzilai
The Companion Dog as a Model for the Longevity Dividend ....... 107
Kate E. Creevy, Steven N. Austad, Jessica M. Hoffman, Dan
G. O'Neill, and Daniel E.L. Promislow
PART II: CLINICAL AND TRANSLATIONAL ASPECTS OF AGING
Translating the Science of Aging into Therapeutic
Interventions ................................................. 121
James L. Kirkland
Interventions for Human Frailty: Physical Activity as
a Model ....................................................... 135
Linda P. Fried
The Aging Heart ............................................... 149
Ying Ann Chiao and Peter S. Rabinovitch
Inhibition of the Mechanistic Target of Rapamycin (mTOR)-
Rapamycin and Beyond .......................................... 165
Dudley W. Lamming
Metformin: A Hopeful Promise in the Aging Research ............ 179
Marta G. Novelle, Ahmed Ali, Carlos Dieguez, Michel Bernier,
and Rafael de Cabo
PART III: SOCIETAL IMPLICATIONS OF DELAYED AGING
Articulating the Case for the Longevity Dividend .............. 191
S. Jay Olshansky
The Economic Promise of Delayed Aging ......................... 197
Dana Goldman
Past, Present, and Future of Healthy Life Expectancy .......... 209
Hiram Beltran-Sdnchez, Samir Soneji, and Eileen M. Crimmins
Has the Rate of Human Aging Already Been Modified? ............ 221
S. Jay Olshansky
Index ......................................................... 239
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